Ancora Imparo

I am still learning
Genographic Project Update
3/31/2007 9:47:16 PM
testkit.jpg

Sponsored by National Geographic, Powered By IBM and underwritten by The Waitt Family Foundation. 

A few months ago, I submitted buccal cells in order to participate in the The Genographic Project. What is that, you ask?  You can read my initial post HERE and read about my concerns regarding the quality of this study HERE.   I was able to print out the results of my genetic lineage directly from the Genographic website.  There are no surprises to be had here as the result of my DNA testing identifies me as belonging to Haplogroup H.

According to this study, my ancestral line goes something like this:

 

 

 

 

“Eve”>L1/L0>L2>L3>N>R>Pre-HV>HV>H  -

not the best scanned image....

 haplogroupHfamilytrail.jpg

 Here are a few interesting facts I’ve discovered about the H haplogroup:

This wave of migration into Western Europe marked the appearance and the spread of what archaeologists call the Aurignacian culture. The culture is distinguished by significant innovations in methods of manufacturing tools.  

15,000 to 20,000 years ago, colder temperatures and a drier global climate (READ: GLOBAL COOLING) locked much of the earth’s freshwater in the polar icecaps, making living nearly impossible in the northern hemisphere. Early migrants retreated to the warmer climates of the Iberian Peninsula, Italy and the Balkans. Their population sizes were drastically reduced.

Beginning around 15,000 years ago when the ice sheets had begun their retreat (READ: GLOBAL WARMING) humans moved north again and recolonized Western Europe. By far the most frequent mitochondrial lineage carried by these groups was haplogroup H. 

Today haplogroup H compromises 40-60 percent of the gene pool of most European populations. In Rome and Athens, for example, the frequency of H is around 40 percent of the entire population, and it exhibits similar frequencies throughout Europe.

The age of haplogroup H lineages differ quite substantially between those seen in the West compared with those found in the East.

HVR1SEQ.jpg

Genographic Study Update
2/4/2007 7:55:00 PM
So, this weekend my Genographic Particpation Kit arrived. As I read through the paperwork and watched the DVD, I discovered that my reasons for hesitation these past two years were right.

No, I do not believe this is all a nefarious government plot to gain unauthorized access to my DNA. My concerns regarding this study are grounded in reality, not based on vague fears and paranoia.

I discovered a glaring discrepancy in the method of collecting the buccal cells for DNA analysis. The DVD has the PI - Dr. Spencer Wells - demonstrating the collection procedure. He instructs the participants to scrape the inside of their cheek for 60 seconds. The writen instructions included with the kit direct participants to scrape the inside of their cheek 'for about 30 seconds'. This is a huge no-no! Inconsistent collection leads to inconsistent results. This study already has participants collecting the sample on their own, virtually a built-in inconsistency; adding to this a discrepancy with the instructions adds another layer to the variation of collection. The structure of this study is a good example of GIGO - Garbage In Garbage Out.

The informational booklet supplied with the kit states "If the project is to be truly global, it must sample the genetic inheritance of us all - and this provides an opportunity for broad public participation as well."

The design of this study contradicts this lofty goal when you take into account the following features of this study:

Cost: $100 plus tax and shipping. I don't care if the test were $1, this is a financial impediment that stratifies the pool of available participants by socio-economic levels. This is not a good way to capture a broad range human DNA samples.

Results are only available to the participant online. This is technological impediment. How many people around the world have easy access to the internet? Adding to this, one must order the kit online. The financial and technical obstacles in this study narrow the pool of likely participants in this study hampering the ability of the researchers to make any determination about our 'deep ancestry'.

I suspect this study was designed not to gather DNA for evil government purposes, but to finance grants for Dr. Wells globe-tripping research.

Where in the World are my Genes?
1/28/2007 11:45:00 AM

After two years of mulling over the idea, I've ordered the Participation Kit for National Geographic's Genographic Project.

What is this, you ask?

The National Geographic Society, IBM, geneticist Spencer Wells, and the Waitt Family Foundation have launched the Genographic Project, a five-year effort to understand the human journey—where we came from and how we got to where we live today. This unprecedented effort will map humanity's genetic journey through the ages.

With a simple and painless cheek swab you can sample your own DNA and submit it to the lab.Your results will reveal your deep ancestry along a single line of direct descent (paternal or maternal) and show the migration paths they followed thousands of years ago. Your results will also place you on a particular branch of the human family tree.
An interesting concept that provides a good primer on human genetics and human pre-history. A cursory review on the net reveals others bloggers who have particpated in this study:


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